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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
Vascular Endothelial Growth Factor 165
|
|
gptkbp:binds
|
gptkb:VEGFR-1
gptkb:VEGFR-2
neuropilin-1
|
|
gptkbp:discoveredIn
|
1990s
|
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gptkbp:encodedBy
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gptkb:VEGFA_gene
|
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gptkbp:Entrez_Gene_ID
|
7422 (VEGFA)
|
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gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
gptkb:placenta
heart
retina
|
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gptkbp:function
|
growth factor activity
increases vascular permeability
stimulates angiogenesis
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gptkbp:GOProcess
|
angiogenesis
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gptkbp:hasIsoform
|
gptkb:VEGF-A
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGF165
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gptkbp:inhibitedBy
|
tyrosine kinase inhibitors
anti-VEGF antibodies
|
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gptkbp:involvedIn
|
wound healing
tumor growth
retinal neovascularization
|
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gptkbp:length
|
165 amino acids
|
|
gptkbp:locatedOnChromosome
|
6p21.1 (VEGFA gene)
|
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gptkbp:molecularWeight
|
~38 kDa (monomer)
|
|
gptkbp:OMIM
|
192240
|
|
gptkbp:PDB
|
1VPF
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:producedBy
|
endothelial cells
tumor cells
|
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gptkbp:promotion
|
gptkb:hypoxia
growth factors
oncogenes
|
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gptkbp:sequenceFeature
|
contains heparin-binding domain
contains receptor-binding domain
|
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gptkbp:significance
|
gptkb:cancer
age-related macular degeneration
diabetic retinopathy
rheumatoid arthritis
|
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gptkbp:species
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gptkb:Mus_musculus
gptkb:Homo_sapiens
|
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gptkbp:structure
|
dimeric protein
|
|
gptkbp:target
|
gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
|
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gptkbp:UniProtID
|
P15692-4
|
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gptkbp:bfsParent
|
gptkb:NRP1
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gptkbp:bfsLayer
|
6
|