Eylea

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:administeredBy ophthalmologist
gptkbp:approvedBy gptkb:European_Union
gptkb:United_States
gptkb:FDA
gptkb:EMA
2011
gptkbp:ATCCode S01LA05
gptkbp:bioavailability local (ocular)
gptkbp:biosimilar yes
gptkbp:blackBoxWarning endophthalmitis risk
gptkbp:brand gptkb:Eylea
gptkbp:chemicalClass recombinant fusion protein
gptkbp:contraindication active intraocular inflammation
ocular infection
gptkbp:cost high
gptkbp:developedBy gptkb:Bayer
gptkb:Regeneron_Pharmaceuticals
gptkbp:drugClass anti-VEGF agent
gptkbp:form injection
solution for injection
gptkbp:frequency every 4 to 8 weeks
gptkbp:genericName gptkb:aflibercept
gptkbp:halfLife ~7 days (ocular)
https://www.w3.org/2000/01/rdf-schema#label Eylea
gptkbp:indication gptkb:diabetic_macular_edema
gptkb:neovascular_age-related_macular_degeneration
diabetic retinopathy
macular edema following retinal vein occlusion
gptkbp:legalStatus prescription only
gptkbp:marketedIn gptkb:European_Union
gptkb:Japan
gptkb:United_States
gptkbp:mechanismOfAction VEGF inhibitor
gptkbp:molecularWeight 115 kDa
gptkbp:patentExpired 2023 (US)
gptkbp:pregnancyCategory C (US)
B3 (Australia)
gptkbp:prescriptionRequired yes
https://www.eylea.us/
gptkbp:routeOfAdministration intravitreal injection
gptkbp:sideEffect glaucoma
conjunctival hemorrhage
eye pain
increased intraocular pressure
vitreous detachment
gptkbp:storage 2-8°C
gptkbp:target gptkb:VEGF-A
gptkb:VEGF-B
gptkb:placental_growth_factor_(PlGF)
gptkbp:bfsParent gptkb:Bayer
gptkb:Lucentis
gptkbp:bfsLayer 5