Vascular Endothelial Growth Factor A

URI: https://gptkb.org/entity/Vascular_Endothelial_Growth_Factor_A
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
growth factor
gptkbp:abbreviation gptkb:VEGF-A
gptkbp:alternativeSplicing produces multiple isoforms
gptkbp:biologicalProcess wound healing
growth factor activity
response to hypoxia
blood vessel development
gptkbp:discoveredBy gptkb:Napoleone_Ferrara
gptkbp:discoveredIn 1989
gptkbp:encodedBy gptkb:VEGFA_gene
gptkbp:Entrez_Gene_ID 7422
ENSG00000112715
gptkbp:expressedIn endothelial cells
tumor cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function increases vascular permeability
promotes endothelial cell growth
stimulates angiogenesis
gptkbp:GOID GO:0038084
https://www.w3.org/2000/01/rdf-schema#label Vascular Endothelial Growth Factor A
gptkbp:inducedBy gptkb:hypoxia
inflammation
gptkbp:InterPro IPR003598
gptkbp:KEGGID hsa:7422
gptkbp:length 165 amino acids (major isoform)
gptkbp:locatedOnChromosome gptkb:chromosome_6p21.1
gptkbp:memberOf gptkb:VEGF_family
gptkbp:molecularWeight ~38 kDa (dimer)
gptkbp:OMIM 192240
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 1VPF
gptkbp:postTranslationalModification glycosylation
disulfide bond formation
gptkbp:proteinFamily PF00341
gptkbp:Reactome R-HSA-194138
gptkbp:recipient gptkb:VEGFR-1
gptkb:VEGFR-2
gptkbp:RefSeq NM_003376
gptkbp:regulates hypoxia-inducible factor 1-alpha (HIF-1α)
gptkbp:significance implicated in cancer
implicated in age-related macular degeneration
implicated in diabetic retinopathy
gptkbp:subunit homodimer
gptkbp:target gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
gptkbp:UniProtID P15692
gptkbp:bfsParent gptkb:VEGF-A
gptkb:VEGF-A_protein
gptkbp:bfsLayer 7