Ubiquitin-specific protease 7

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:USP7 gptkb:HAUSP
gptkbp:associatedWith	gptkb:cancer neurodegenerative diseases
gptkbp:discoveredBy	Nicholas P. Dantuma et al.
gptkbp:discoveredIn	1997
gptkbp:encodedBy	gptkb:USP7_gene
gptkbp:Entrez_Gene_ID	7874
gptkbp:enzymeCommissionNumber	gptkb:EC_3.4.19.12
gptkbp:function	deubiquitinating enzyme removes ubiquitin from target proteins
https://www.w3.org/2000/01/rdf-schema#label	Ubiquitin-specific protease 7
gptkbp:interactsWith	gptkb:FOXO4 gptkb:USP10 gptkb:MDM2 gptkb:PTEN gptkb:p53 gptkb:DNMT1 EBNA1 USP11 USP15 USP47
gptkbp:involvedIn	gptkb:ubiquitin-proteasome_pathway cell cycle regulation epigenetic regulation DNA damage response
gptkbp:locatedOnChromosome	16p13.2
gptkbp:location	gptkb:nucleus
gptkbp:molecularWeight	135 kDa
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Drosophila_melanogaster
gptkbp:PDB	1NB8
gptkbp:postTranslationalModification	phosphorylation sumoylation
gptkbp:RefSeq	NP_003461.2
gptkbp:regulates	gptkb:FOXO4 gptkb:MDM2 gptkb:PTEN gptkb:DNMT1 p53 protein stability
gptkbp:structure	contains catalytic domain contains ubiquitin-like domains contains TRAF-like domain
gptkbp:target	small molecule inhibitors
gptkbp:UniProtID	gptkb:Q93009
gptkbp:bfsParent	gptkb:USP7
gptkbp:bfsLayer	7