|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:HAUSP
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodevelopmental disorders
|
|
gptkbp:biologicalProcess
|
thiol-dependent ubiquitin-specific protease activity
|
|
gptkbp:component
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
Li et al.
|
|
gptkbp:encodes
|
Ubiquitin carboxyl-terminal hydrolase 7
|
|
gptkbp:Entrez_Gene_ID
|
7874
ENSG00000104447
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1997
|
|
gptkbp:function
|
deubiquitinating enzyme
ubiquitin-specific protease activity
|
|
gptkbp:GOProcess
|
protein deubiquitination
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
USP7 gene
|
|
gptkbp:interactsWith
|
gptkb:FOXO4
gptkb:USP10
gptkb:USP33
gptkb:MDM2
gptkb:PTEN
gptkb:p53
gptkb:USP25
gptkb:DNMT1
gptkb:ICP0_(Herpes_simplex_virus_protein)
USP9X
USP11
USP15
USP2
USP20
USP21
USP22
USP28
USP4
USP42
USP44
USP47
USP8
|
|
gptkbp:involvedIn
|
DNA damage response
protein ubiquitination
regulation of p53
|
|
gptkbp:length
|
1102 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_16
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autism_spectrum_disorder
intellectual disability
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Usp7
|
|
gptkbp:proteinFamily
|
peptidase C19 family
|
|
gptkbp:regulates
|
gptkb:MDM2
gptkb:p53
|
|
gptkbp:target
|
small molecule inhibitors
|
|
gptkbp:UniProtID
|
gptkb:Q93009
|
|
gptkbp:bfsParent
|
gptkb:USP7
|
|
gptkbp:bfsLayer
|
7
|