Statements (64)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
epigenetic regulation
|
| gptkbp:conservation |
gptkb:evolution
|
| gptkbp:discovered_by |
research studies
|
| gptkbp:form |
DNMT1a
DNMT1b |
| gptkbp:function |
DNA methylation
|
| gptkbp:genetic_studies |
gptkb:Oncology
|
| gptkbp:has_role |
gene expression
|
| https://www.w3.org/2000/01/rdf-schema#label |
DNMT1
|
| gptkbp:initiated_by |
decitabine
azacitidine |
| gptkbp:interacts_with |
gptkb:DNA
|
| gptkbp:involved_in |
cell differentiation
|
| gptkbp:is_associated_with |
hypomethylation
hypermethylation |
| gptkbp:is_downregulated_in |
gptkb:neurodegenerative_diseases
|
| gptkbp:is_essential_for |
gptkb:developers
|
| gptkbp:is_expressed_in |
various tissues
embryogenesis embryonic stem cells |
| gptkbp:is_involved_in |
X-chromosome inactivation
apoptosis cell cycle regulation cellular homeostasis immune response metabolic processes wound healing neuroplasticity stress response cognitive functions DNA repair mechanisms synaptic plasticity tumor microenvironment cellular aging cellular differentiation tissue regeneration neural development metastasis cellular signaling neurodevelopmental disorders drug metabolism therapeutic resistance behavioral responses reproductive biology cardiovascular development genomic imprinting immunological processes environmental responses learning and memory. |
| gptkbp:is_linked_to |
aging
tumorigenesis stem cell maintenance |
| gptkbp:is_regulated_by |
transcription factors
|
| gptkbp:is_studied_in |
epigenetics research
|
| gptkbp:is_targeted_at |
epigenetic drugs
|
| gptkbp:is_upregulated_in |
gptkb:Oncology
|
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:orthologs |
many species
|
| gptkbp:part_of |
DNA methyltransferase family
|
| gptkbp:regulates |
gene silencing
|
| gptkbp:weight |
approximately 200 k Da
|
| gptkbp:bfsParent |
gptkb:DNMT3_A
|
| gptkbp:bfsLayer |
6
|