|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:DNA_methyltransferase_1
DNMT1A
DNMT1B
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
imprinting disorders
|
|
gptkbp:biologicalProcess
|
DNA replication
gene silencing
chromatin modification
DNA methyltransferase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
gptkb:Arthur_Riggs
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:Entrez_Gene_ID
|
1786
ENSG00000130816
|
|
gptkbp:enzymeCommissionNumber
|
2.1.1.37
|
|
gptkbp:expressedIn
|
most somatic tissues
|
|
gptkbp:fullName
|
DNA (cytosine-5)-methyltransferase 1
|
|
gptkbp:function
|
epigenetic regulation
maintenance DNA methylation
|
|
gptkbp:gene
|
gptkb:DNMT1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
NM_001130823.2
NM_001379.4
|
|
gptkbp:HGNC_ID
|
2976
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DNMT1
|
|
gptkbp:inhibitedBy
|
gptkb:5-azacytidine
gptkb:decitabine
|
|
gptkbp:interactsWith
|
gptkb:G9a
gptkb:HDAC1
gptkb:PCNA
UHRF1
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.2
19
|
|
gptkbp:mutationAssociatedWith
|
autosomal dominant cerebellar ataxia, deafness, and narcolepsy
hereditary sensory and autonomic neuropathy type IE
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Dnmt1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:regulates
|
DNA methylation patterns
|
|
gptkbp:requires
|
cell proliferation
embryonic development
|
|
gptkbp:UniProtID
|
P26358
|
|
gptkbp:bfsParent
|
gptkb:USP7
gptkb:DNA_methyltransferase
|
|
gptkbp:bfsLayer
|
7
|