|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
JAK2B
Janus kinase 2B
TYK2 protein
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
multiple sclerosis
autoimmune diseases
psoriasis
immunodeficiency
inflammatory bowel disease
|
|
gptkbp:biologicalProcess
|
protein tyrosine kinase activity
|
|
gptkbp:discoveredBy
|
Firmbach-Kraft et al.
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodedBy
|
TYK2 gene
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.10.2
|
|
gptkbp:function
|
signal transduction
cytokine signaling
|
|
gptkbp:gene
|
gptkb:TYK2
|
|
gptkbp:HGNC_ID
|
HGNC:12440
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tyrosine kinase 2
|
|
gptkbp:interactsWith
|
gptkb:STAT1
gptkb:JAK1
gptkb:STAT4
gptkb:STAT5A
gptkb:STAT5B
gptkb:STAT3
gptkb:IFNAR1
gptkb:IL10RB
IFNAR2
IL12RB1
|
|
gptkbp:involves
|
gptkb:JAK-STAT_signaling_pathway
|
|
gptkbp:length
|
1187
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
|
gptkbp:member
|
gptkb:Janus_kinase_family
|
|
gptkbp:molecularWeight
|
133 kDa
|
|
gptkbp:OMIM
|
176941
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
4OLI
6N7A
|
|
gptkbp:phosphorylates
|
gptkb:STAT1
gptkb:STAT4
gptkb:STAT5A
gptkb:STAT5B
gptkb:STAT3
|
|
gptkbp:RefSeq
|
NP_003322.4
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
pharmaceutical inhibitors
|
|
gptkbp:UniProtID
|
P29597
|
|
gptkbp:bfsParent
|
gptkb:TYK2
|
|
gptkbp:bfsLayer
|
8
|