|
gptkbp:instanceOf
|
immune response
T cell subtype
|
|
gptkbp:abnormalityAssociatedWith
|
gptkb:allergy
cancer progression
autoimmune disease
|
|
gptkbp:depletedIn
|
autoimmune diseases
|
|
gptkbp:developmentDependsOn
|
FOXP3 gene
|
|
gptkbp:discoveredBy
|
gptkb:Shimon_Sakaguchi
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:enhancedIn
|
tumor microenvironment
|
|
gptkbp:expressedIn
|
gptkb:CTLA-4
gptkb:GITR
gptkb:CD39
CD73
CD127 (low)
|
|
gptkbp:foundIn
|
lymph nodes
spleen
peripheral blood
|
|
gptkbp:fullName
|
gptkb:regulatory_T_cells
|
|
gptkbp:function
|
immune tolerance
suppression of immune response
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Treg cells
|
|
gptkbp:inhibitedBy
|
inflammatory response
autoimmune response
|
|
gptkbp:marking
|
gptkb:FOXP3
gptkb:CD4
gptkb:CD25
CD4+CD25+FOXP3+
|
|
gptkbp:mutationInFOXP3Causes
|
IPEX syndrome
|
|
gptkbp:origin
|
gptkb:thymus
periphery
|
|
gptkbp:proliferationInducedBy
|
gptkb:IL-2
gptkb:TGF-beta
|
|
gptkbp:proportionOfCD4Tcells
|
5-10%
|
|
gptkbp:role
|
cancer immune evasion
transplant tolerance
autoimmunity prevention
|
|
gptkbp:secretes
|
gptkb:IL-10
gptkb:TGF-beta
|
|
gptkbp:subspecies
|
induced Treg (iTreg)
natural Treg (nTreg)
|
|
gptkbp:suppressedBy
|
gptkb:NK_cells
gptkb:B_cells
dendritic cells
effector T cells
|
|
gptkbp:suppressVia
|
cell-cell contact
cytokine secretion
|
|
gptkbp:targetOfDrug
|
immunotherapy
autoimmune therapy
|
|
gptkbp:bfsParent
|
gptkb:CD4+_T_cells
|
|
gptkbp:bfsLayer
|
6
|