|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
ENTPD1
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
thrombosis
|
|
gptkbp:cellSurfaceMarker
|
yes
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodedBy
|
ENTPD1 gene
|
|
gptkbp:expressedIn
|
platelets
endothelial cells
immune cells
lymphocytes
|
|
gptkbp:family
|
ecto-nucleotidase family
|
|
gptkbp:fullName
|
Ectonucleoside triphosphate diphosphohydrolase 1
|
|
gptkbp:function
|
hydrolyzes extracellular ATP and ADP to AMP
regulates purinergic signaling
|
|
gptkbp:gene
|
ENTPD1
|
|
gptkbp:glycoprotein
|
yes
|
|
gptkbp:HGNC_ID
|
3341
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD39
|
|
gptkbp:inhibitedBy
|
ARL 67156
POM-1
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
10q24
|
|
gptkbp:molecularWeight
|
~58 kDa
|
|
gptkbp:OMIM
|
601752
|
|
gptkbp:orthologInMouse
|
Entpd1
|
|
gptkbp:partner
|
CD73
|
|
gptkbp:pathway
|
adenosine production pathway
purinergic signaling pathway
|
|
gptkbp:PDB
|
3ZX3
|
|
gptkbp:product
|
gptkb:AMP
|
|
gptkbp:regulates
|
platelet aggregation
T cell function
vascular inflammation
extracellular nucleotide levels
|
|
gptkbp:role
|
inflammation
cancer immunology
immune regulation
thromboregulation
|
|
gptkbp:structure
|
two transmembrane domains
|
|
gptkbp:substrate
|
gptkb:ATP
gptkb:ADP
|
|
gptkbp:target
|
immunotherapy
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
P49961
|
|
gptkbp:bfsParent
|
gptkb:regulatory_T_cells
gptkb:Treg_cells
|
|
gptkbp:bfsLayer
|
7
|