|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:NF-κB_pathway
type I interferon production
|
|
gptkbp:alias
|
gptkb:CD289
Toll/interleukin-1 receptor-like protein 9
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:systemic_lupus_erythematosus
autoimmune diseases
infections
|
|
gptkbp:discoveredBy
|
Shizuo Akira
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:encodedBy
|
gptkb:TLR9_gene
|
|
gptkbp:Entrez_Gene_ID
|
54106
|
|
gptkbp:expressedIn
|
gptkb:B_cells
gptkb:plasmacytoid_dendritic_cells
macrophages
monocytes
|
|
gptkbp:foundIn
|
humans
mice
|
|
gptkbp:fullName
|
Toll-like receptor 9
|
|
gptkbp:function
|
initiates innate immune response
recognizes unmethylated CpG DNA
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
11850
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TLR9
|
|
gptkbp:inhibitedBy
|
chloroquine
hydroxychloroquine
|
|
gptkbp:ligand
|
unmethylated CpG motifs
|
|
gptkbp:locatedOnChromosome
|
chromosome 3p21.3 (human)
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
endolysosome
|
|
gptkbp:OMIM
|
605474
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:pathway
|
gptkb:Toll-like_receptor_signaling_pathway
|
|
gptkbp:PDB
|
3WPF
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:proteinFamily
|
gptkb:Toll-like_receptor_family
|
|
gptkbp:regulates
|
inflammatory response
cytokine production
|
|
gptkbp:reviewedBy
|
gptkb:Journal_of_Immunology
gptkb:Nature_Immunology
|
|
gptkbp:structure
|
TIR domain
leucine-rich repeat (LRR) domain
|
|
gptkbp:target
|
immunotherapy
vaccine adjuvants
|
|
gptkbp:UniProtID
|
gptkb:Q9NR96
|
|
gptkbp:bfsParent
|
gptkb:Toll-like_receptors
|
|
gptkbp:bfsLayer
|
7
|