|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:NF-kappaB_pathway
IRF3 pathway
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:herpes_simplex_encephalitis
autoimmune diseases
viral infection response
|
|
gptkbp:discoveredBy
|
gptkb:Bruce_Beutler
|
|
gptkbp:discoveredIn
|
2001
|
|
gptkbp:encodedBy
|
gptkb:TLR3_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000164342
|
|
gptkbp:expressedIn
|
dendritic cells
macrophages
fibroblasts
epithelial cells
|
|
gptkbp:family
|
gptkb:Toll-like_receptor_family
|
|
gptkbp:fullName
|
gptkb:Toll-like_receptor_3
|
|
gptkbp:function
|
innate immune response
pattern recognition receptor
|
|
gptkbp:gene
|
gptkb:TLR3
|
|
gptkbp:GO_term
|
GO:0002221
|
|
gptkbp:HGNC_ID
|
11849
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TLR3
|
|
gptkbp:inducedBy
|
pro-inflammatory cytokines
type I interferon production
|
|
gptkbp:inhibitedBy
|
chloroquine
hydroxychloroquine
|
|
gptkbp:interactsWith
|
TRIF
TICAM-1
UNC93B1
|
|
gptkbp:length
|
904 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
4q35
|
|
gptkbp:location
|
gptkb:endosome
cell surface
|
|
gptkbp:molecularWeight
|
104 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased susceptibility to viral infections
herpes simplex virus encephalitis
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2A0Z
|
|
gptkbp:recognizedBy
|
double-stranded RNA
|
|
gptkbp:RefSeq
|
NM_003265
|
|
gptkbp:structure
|
transmembrane domain
leucine-rich repeat
TIR domain
|
|
gptkbp:UniProtID
|
O15455
|
|
gptkbp:bfsParent
|
gptkb:Toll-like_receptors
|
|
gptkbp:bfsLayer
|
7
|