Toll-like receptor family

URI: https://gptkb.org/entity/Toll-like_receptor_family

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:activatedBy	gptkb:NF-κB_pathway cytokine production
gptkbp:contains	gptkb:TLR2 gptkb:TLR4 gptkb:TLR1 gptkb:TLR10 gptkb:TLR3 gptkb:TLR5 gptkb:TLR6 gptkb:TLR8 gptkb:TLR9 TLR7 TLR11 TLR12 TLR13
gptkbp:discoveredIn	gptkb:Drosophila_melanogaster
gptkbp:domain	leucine-rich repeat TIR domain
gptkbp:expressedIn	gptkb:B_cells dendritic cells macrophages immune cells epithelial cells
gptkbp:firstDescribed	1997
gptkbp:foundIn	animals
gptkbp:function	innate immune response pathogen recognition
https://www.w3.org/2000/01/rdf-schema#label	Toll-like receptor family
gptkbp:involvedIn	inflammation antiviral response bacterial recognition fungal recognition parasitic recognition
gptkbp:involves	gptkb:cancer infectious diseases autoimmune diseases inflammatory diseases
gptkbp:ligand	pathogen-associated molecular patterns
gptkbp:locatedOnChromosome	chromosome 4 (human TLRs) chromosome 9 (human TLRs) chromosome X (human TLRs)
gptkbp:namedAfter	Toll gene
gptkbp:orthologIn	Drosophila Toll protein
gptkbp:recipient	pattern recognition receptor
gptkbp:relatedTo	interleukin-1 receptor family
gptkbp:studiedIn	immunology
gptkbp:bfsParent	gptkb:CD281 gptkb:CD285 gptkb:CD287 gptkb:CD289 gptkb:TLR1 gptkb:TLR10 gptkb:TLR3 gptkb:TLR5 gptkb:TLR6 gptkb:TLR8 gptkb:TLR9
gptkbp:bfsLayer	8