|
gptkbp:instanceOf
|
T helper cell
|
|
gptkbp:activatedBy
|
gptkb:MHC_class_II
antigen-presenting cell
|
|
gptkbp:cytokineProfile
|
IL-4, IL-5, IL-13, IL-10, IL-9
|
|
gptkbp:differentiationInducedBy
|
gptkb:IL-4
|
|
gptkbp:discoveredBy
|
Timothy Mosmann
|
|
gptkbp:enemyOf
|
gptkb:Th17_cell
gptkb:Th1_cell
|
|
gptkbp:expressedIn
|
cell surface receptor
|
|
gptkbp:function
|
promote humoral immunity
stimulate B cell antibody production
involved in allergic response
defense against extracellular parasites
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Th2 cell
|
|
gptkbp:inhibitedBy
|
macrophage activation
|
|
gptkbp:involvedIn
|
mucosal immunity
allergic inflammation
antibody class switching
type 2 immune response
defense against helminths
|
|
gptkbp:location
|
lymph nodes
spleen
peripheral blood
|
|
gptkbp:marking
|
gptkb:GATA3
gptkb:CCR4
gptkb:CRTH2
gptkb:CD4
|
|
gptkbp:originatedIn
|
naive CD4+ T cell
|
|
gptkbp:produces
|
gptkb:IL-10
gptkb:IL-4
gptkb:IL-5
gptkb:IL-13
IL-9
|
|
gptkbp:promotion
|
eosinophil activation
IgE production
mast cell activation
|
|
gptkbp:regulates
|
gptkb:GATA3
gptkb:STAT6
|
|
gptkbp:role
|
gptkb:atopic_dermatitis
asthma
allergic rhinitis
helminth infection
|
|
gptkbp:subclassOf
|
gptkb:CD4+_T_cell
|
|
gptkbp:surfaceProtein
|
gptkb:CD28
gptkb:CD3
gptkb:CD40L
|
|
gptkbp:bfsParent
|
gptkb:T4_cell
gptkb:CD4+_T_cell
gptkb:helper_T_cell_(CD4+)
|
|
gptkbp:bfsLayer
|
7
|