|
gptkbp:instanceOf
|
cell surface receptor
|
|
gptkbp:activatedBy
|
antigen-presenting cell
|
|
gptkbp:alsoKnownAs
|
T helper cell
|
|
gptkbp:canBe
|
gptkb:effector_T_cell
memory T cell
|
|
gptkbp:compatibleWith
|
gptkb:CD8+_T_cell
|
|
gptkbp:decreasedIn
|
gptkb:AIDS
|
|
gptkbp:developedBy
|
thymocyte
|
|
gptkbp:distinctiveFeature
|
gptkb:Th17_cell
gptkb:Th1_cell
gptkb:Th2_cell
gptkb:Treg_cell
|
|
gptkbp:expressedIn
|
gptkb:CD4_glycoprotein
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:foundIn
|
blood
lymphoid tissue
|
|
gptkbp:function
|
cytokine production
immune response regulation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD4+ T cell
|
|
gptkbp:importantFor
|
cell-mediated immunity
humoral immunity
|
|
gptkbp:involvedIn
|
autoimmune diseases
immunodeficiency
allergic reactions
|
|
gptkbp:involves
|
transplant rejection
|
|
gptkbp:lifespan
|
years
|
|
gptkbp:marking
|
gptkb:CD28
gptkb:CD3
gptkb:CD4
gptkb:T_cell_receptor_(TCR)
|
|
gptkbp:maturation
|
gptkb:thymus
|
|
gptkbp:originatedIn
|
bone marrow
|
|
gptkbp:percentageOf
|
~60% of circulating T cells
|
|
gptkbp:produces
|
gptkb:interferon-gamma
gptkb:interleukin-2
gptkb:interleukin-4
interleukin-17
|
|
gptkbp:proliferatesInResponseTo
|
immune response
|
|
gptkbp:receptorFor
|
gptkb:MHC_class_II_molecules
|
|
gptkbp:recognizedBy
|
flow cytometry
|
|
gptkbp:regulates
|
B cell activation
macrophage activation
CD8+ T cell response
|
|
gptkbp:requires
|
vaccine response
|
|
gptkbp:role
|
adaptive immunity
|
|
gptkbp:secretes
|
cytokines
|
|
gptkbp:subspecies
|
lymphocyte
|
|
gptkbp:target
|
gptkb:HIV
|
|
gptkbp:bfsParent
|
gptkb:HIV-1
gptkb:Human_Immunodeficiency_Virus
gptkb:MHC_molecule
|
|
gptkbp:bfsLayer
|
6
|