|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:GATA-binding_factor_3
gptkb:GATA-3
HDR
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:hypoparathyroidism,_sensorineural_deafness,_and_renal_dysplasia_syndrome_(HDR_syndrome)
gptkb:T-cell_acute_lymphoblastic_leukemia
|
|
gptkbp:biologicalProcess
|
cell differentiation
DNA binding
organ development
immune system process
transcriptional activator activity
|
|
gptkbp:discoveredBy
|
gptkb:Yamamoto_et_al.
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:domain
|
zinc finger domain
|
|
gptkbp:encodes
|
gptkb:GATA_binding_protein_3
|
|
gptkbp:Entrez_Gene_ID
|
2625
ENSG00000107485
|
|
gptkbp:essentialGene
|
yes
|
|
gptkbp:expressedIn
|
T lymphocytes
breast tissue
|
|
gptkbp:function
|
transcription factor
regulation of immune response
regulation of T-cell development
|
|
gptkbp:gene
|
gptkb:GATA3
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasClinicalTest
|
immunohistochemistry for breast cancer diagnosis
|
|
gptkbp:hasMouseKnockoutPhenotype
|
abnormal T cell development
|
|
gptkbp:HGNC_ID
|
4171
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GATA3
|
|
gptkbp:length
|
444 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
gptkb:10p14
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
cancer susceptibility
|
|
gptkbp:OMIM
|
131320
|
|
gptkbp:orthologInMouse
|
gptkb:Gata3
|
|
gptkbp:proteinFamily
|
gptkb:GATA_family_of_transcription_factors
|
|
gptkbp:regulates
|
Th2 cell differentiation
IL-13 expression
IL-4 expression
IL-5 expression
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:target
|
microRNAs
pharmacological inhibitors
|
|
gptkbp:transcriptionRegulator
|
yes
|
|
gptkbp:UniProtID
|
gptkb:P23771
|
|
gptkbp:bfsParent
|
gptkb:chromosome_10
|
|
gptkbp:bfsLayer
|
6
|