Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:discoveredIn |
1982
|
| gptkbp:enemyOf |
gptkb:Dupilumab
Pitrakinra |
| gptkbp:Entrez_Gene_ID |
3565
|
| gptkbp:fullName |
Interleukin-4
|
| gptkbp:function |
induces class switching to IgE
inhibits Th1 cell differentiation stimulates B cell proliferation promotes differentiation of naive T cells to Th2 cells induces class switching to IgG1 |
| gptkbp:gene |
gptkb:IL4
|
| https://www.w3.org/2000/01/rdf-schema#label |
IL-4
|
| gptkbp:inducedBy |
IgE synthesis
VCAM-1 expression STAT6 activation chemokine production GATA3 expression IL-13 production IL-5 production IgG4 synthesis |
| gptkbp:inhibitedBy |
macrophage activation
IFN-γ production Th1 cytokine production |
| gptkbp:involvedIn |
asthma
allergic response immune regulation |
| gptkbp:locatedOnChromosome |
5q31.1
|
| gptkbp:medicalUse |
targeted in asthma therapy
targeted in atopic dermatitis therapy |
| gptkbp:molecularWeight |
15 kDa
|
| gptkbp:OMIM |
147780
|
| gptkbp:orthologInMouse |
gptkb:Il4
|
| gptkbp:PDB |
2B8U
|
| gptkbp:producedBy |
gptkb:basophils
gptkb:mast_cells gptkb:T_helper_2_cells |
| gptkbp:promotion |
CD23 expression
MHC class II expression B cell survival |
| gptkbp:receptorSubunit |
gptkb:IL-4Rα
gptkb:common_gamma_chain |
| gptkbp:recipient |
gptkb:IL-4_receptor
|
| gptkbp:regulates |
fibrosis
eosinophil migration tissue remodeling alternative macrophage activation |
| gptkbp:structure |
four-helix bundle
|
| gptkbp:UniProtID |
P05112
|
| gptkbp:bfsParent |
gptkb:interleukin-4
gptkb:IgE gptkb:IFN-γ gptkb:IL-13 gptkb:IL4_gene gptkb:Interleukin_4 gptkb:Tfh_cells gptkb:Th2_cells |
| gptkbp:bfsLayer |
7
|