|
gptkbp:instanceOf
|
T helper cell subtype
|
|
gptkbp:associatedWith
|
multiple sclerosis
autoimmune diseases
psoriasis
rheumatoid arthritis
inflammatory bowel disease
|
|
gptkbp:differentiationDrivenBy
|
gptkb:TGF-beta
gptkb:IL-6
IL-23
IL-1beta
|
|
gptkbp:discoveredBy
|
gptkb:Chen_Dong
Dan Cua
|
|
gptkbp:discoveredIn
|
2005
|
|
gptkbp:enemyOf
|
gptkb:IL-10
gptkb:IL-4
gptkb:regulatory_T_cells
gptkb:IFN-gamma
|
|
gptkbp:expressedIn
|
gptkb:IL-17A
CCR6
IL-23R
RORγt
IL-17F
IL-22
|
|
gptkbp:function
|
defense against extracellular bacteria
defense against fungi
pro-inflammatory response
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Th17 cell
|
|
gptkbp:location
|
gptkb:cancer
gptkb:skin
mucosal tissues
intestinal lamina propria
|
|
gptkbp:marking
|
CCR6
CD161
IL-23R
|
|
gptkbp:masterTranscriptionFactor
|
RORγt
|
|
gptkbp:produces
|
gptkb:GM-CSF
gptkb:IL-17A
IL-21
IL-17F
IL-22
|
|
gptkbp:relatedTo
|
gptkb:Th1_cell
gptkb:Th2_cell
gptkb:Treg_cell
|
|
gptkbp:role
|
inflammation
autoimmunity
host defense
|
|
gptkbp:bfsParent
|
gptkb:T4_cell
gptkb:CD4+_T_cell
gptkb:helper_T_cell_(CD4+)
|
|
gptkbp:bfsLayer
|
7
|