|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:CD154
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:binds
|
gptkb:CD40
|
|
gptkbp:biologicalProcess
|
immune system process
receptor binding
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
CD40LG gene
|
|
gptkbp:Entrez_Gene_ID
|
CD40LG
ENSG00000102245
|
|
gptkbp:expressedIn
|
platelets
activated T cells
|
|
gptkbp:foundIn
|
humans
mice
|
|
gptkbp:function
|
B cell activation
immune response regulation
germinal center formation
isotype switching
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
11935
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD40L
|
|
gptkbp:involvedIn
|
autoimmune diseases
inflammatory response
T cell-dependent B cell activation
|
|
gptkbp:involves
|
gptkb:systemic_lupus_erythematosus
atherosclerosis
immunodeficiency
rheumatoid arthritis
|
|
gptkbp:length
|
261 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:X_chromosome
Xq26
|
|
gptkbp:memberOf
|
tumor necrosis factor (TNF) superfamily
|
|
gptkbp:molecularWeight
|
29 kDa
|
|
gptkbp:mutationAssociatedWith
|
X-linked hyper-IgM syndrome
|
|
gptkbp:OMIM
|
300386
|
|
gptkbp:orthologIn
|
gptkb:lion
gptkb:mouse
right
|
|
gptkbp:PDB
|
1ALY
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
macrophage activation
antibody class switching
dendritic cell maturation
|
|
gptkbp:structure
|
type II transmembrane protein
|
|
gptkbp:target
|
therapeutic antibodies
|
|
gptkbp:UniProtID
|
P29965
|
|
gptkbp:bfsParent
|
gptkb:Th2_cell
gptkb:ITGAM_gene
gptkb:CD40
gptkb:TNFRSF
|
|
gptkbp:bfsLayer
|
8
|