Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
immune response
T cell subtype |
| gptkbp:abbreviation |
Treg
|
| gptkbp:cytokineProduction |
gptkb:IL-10
gptkb:TGF-beta IL-35 |
| gptkbp:discoveredBy |
gptkb:Shimon_Sakaguchi
|
| gptkbp:expressedIn |
gptkb:CTLA-4
gptkb:GITR gptkb:IL-2_receptor_alpha_chain CD127 (low) |
| gptkbp:firstDescribed |
1995
|
| gptkbp:fullName |
regulatory T cell
|
| gptkbp:function |
immune tolerance
suppression of immune response |
| https://www.w3.org/2000/01/rdf-schema#label |
Treg cell
|
| gptkbp:inhibitedBy |
gptkb:B_cells
dendritic cells effector T cells |
| gptkbp:marking |
gptkb:FOXP3
gptkb:CD4 gptkb:CD25 CD127low CD25+ CD4+ FOXP3+ |
| gptkbp:mechanismOfAction |
cell-cell contact
cytokine secretion metabolic disruption modulation of antigen-presenting cells |
| gptkbp:origin |
gptkb:thymus
periphery |
| gptkbp:regulates |
gptkb:FOXP3
inflammation autoimmunity allergic response transplant rejection |
| gptkbp:relatedTo |
multiple sclerosis
rheumatoid arthritis tumor microenvironment autoimmune diabetes allograft tolerance |
| gptkbp:role |
gptkb:cancer
autoimmune diseases chronic infection |
| gptkbp:roleInTherapy |
immunotherapy
tolerance induction |
| gptkbp:subspecies |
induced Treg (iTreg)
natural Treg (nTreg) |
| gptkbp:bfsParent |
gptkb:T4_cell
gptkb:CD4+_T_cell |
| gptkbp:bfsLayer |
7
|