|
gptkbp:instanceOf
|
gptkb:immune_response
gptkb:T_cell_subtype
|
|
gptkbp:abbreviation
|
Treg
|
|
gptkbp:cytokineProduction
|
gptkb:IL-10
gptkb:TGF-beta
IL-35
|
|
gptkbp:discoveredBy
|
gptkb:Shimon_Sakaguchi
|
|
gptkbp:expressedIn
|
gptkb:CTLA-4
gptkb:GITR
gptkb:IL-2_receptor_alpha_chain
CD127 (low)
|
|
gptkbp:firstDescribed
|
1995
|
|
gptkbp:fullName
|
regulatory T cell
|
|
gptkbp:function
|
immune tolerance
suppression of immune response
|
|
gptkbp:inhibitedBy
|
gptkb:B_cells
dendritic cells
effector T cells
|
|
gptkbp:marking
|
gptkb:FOXP3
gptkb:CD4
gptkb:CD25
CD127low
CD25+
CD4+
FOXP3+
|
|
gptkbp:mechanismOfAction
|
cell-cell contact
cytokine secretion
metabolic disruption
modulation of antigen-presenting cells
|
|
gptkbp:origin
|
gptkb:thymus
periphery
|
|
gptkbp:regulates
|
gptkb:FOXP3
inflammation
autoimmunity
allergic response
transplant rejection
|
|
gptkbp:relatedTo
|
multiple sclerosis
rheumatoid arthritis
tumor microenvironment
autoimmune diabetes
allograft tolerance
|
|
gptkbp:role
|
gptkb:cancer
autoimmune diseases
chronic infection
|
|
gptkbp:roleInTherapy
|
gptkb:immunotherapy
tolerance induction
|
|
gptkbp:subspecies
|
induced Treg (iTreg)
natural Treg (nTreg)
|
|
gptkbp:bfsParent
|
gptkb:T4_cell
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Treg cell
|