|
gptkbp:instanceOf
|
gptkb:Cell
|
|
gptkbp:cytokineProduced
|
gptkb:IL-4
IL-21
|
|
gptkbp:differentiationRegulatedBy
|
gptkb:STAT3
gptkb:IL-6
Bcl6
ICOS signaling
IL-21
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:immunodeficiency
autoimmune diseases
lymphomas
|
|
gptkbp:expressedIn
|
gptkb:CXCR5
gptkb:ICOS
gptkb:PD-1
Bcl6
|
|
gptkbp:firstDescribed
|
2000
|
|
gptkbp:fullName
|
gptkb:T_follicular_helper_cells
|
|
gptkbp:function
|
help B cells produce antibodies
|
|
gptkbp:importantFor
|
vaccine efficacy
long-lived antibody responses
|
|
gptkbp:interactsWith
|
gptkb:B_cells
gptkb:follicular_dendritic_cells
|
|
gptkbp:involvedIn
|
B cell selection
humoral immunity
antibody class switching
|
|
gptkbp:location
|
germinal centers
|
|
gptkbp:marking
|
gptkb:CXCR5
gptkb:ICOS
gptkb:PD-1
Bcl6+
CXCR5+
ICOS+
PD-1+
|
|
gptkbp:originatedIn
|
gptkb:CD4+_T_cells
|
|
gptkbp:regulates
|
Bcl6
|
|
gptkbp:relatedTo
|
gptkb:Th17_cells
gptkb:Th1_cells
gptkb:Th2_cells
gptkb:Treg_cells
|
|
gptkbp:role
|
adaptive immune response
germinal center formation
affinity maturation
isotype switching
|
|
gptkbp:secretes
|
gptkb:IL-4
IL-21
|
|
gptkbp:subspecies
|
gptkb:CD4+_T_cells
|
|
gptkbp:bfsParent
|
gptkb:CD4+_T_cells
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tfh cells
|