Statements (40)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
T helper cell subtype
|
| gptkbp:differentiationDrivenBy |
gptkb:TGF-beta
gptkb:IL-6 IL-23 |
| gptkbp:discoveredBy |
Dan Cua
|
| gptkbp:discoveredIn |
2005
|
| gptkbp:enemyOf |
gptkb:IL-10
gptkb:IFN-gamma regulatory T cells (Tregs) |
| gptkbp:function |
defense against extracellular bacteria
defense against fungi pro-inflammatory response |
| https://www.w3.org/2000/01/rdf-schema#label |
Th17 cells
|
| gptkbp:involves |
multiple sclerosis
autoimmune diseases psoriasis rheumatoid arthritis inflammatory bowel disease |
| gptkbp:location |
gptkb:cancer
gptkb:skin mucosal tissues intestinal lamina propria |
| gptkbp:marking |
CCR6
CD161 IL-23R |
| gptkbp:originatedIn |
naive CD4+ T cells
|
| gptkbp:produces |
interleukin-17 (IL-17)
interleukin-21 (IL-21) interleukin-22 (IL-22) |
| gptkbp:regulates |
gptkb:STAT3
RORγt |
| gptkbp:relatedTo |
gptkb:Th1_cells
gptkb:Th2_cells gptkb:Treg_cells |
| gptkbp:role |
autoimmunity
chronic inflammation host defense |
| gptkbp:bfsParent |
gptkb:CD4+_T_cells
gptkb:interleukin-17A |
| gptkbp:bfsLayer |
6
|