|
gptkbp:instance_of
|
gptkb:protein
|
|
gptkbp:associated_with
|
cancer immunotherapy
T cell regulation
|
|
gptkbp:discovered_by
|
gptkb:1992
|
|
gptkbp:diseases
|
gptkb:disease
gptkb:asthma
gptkb:chronic_fatigue_syndrome
gptkb:Crohn's_disease
gptkb:systemic_lupus_erythematosus
gptkb:ulcerative_colitis
gptkb:Oncology
gptkb:pancreatic_cancer
gptkb:rheumatoid_arthritis
gptkb:multiple_sclerosis
ovarian cancer
urticaria
fibromyalgia
hay fever
liver cancer
eczema
psoriasis
anaphylaxis
food allergies
atopic dermatitis
type 1 diabetes
esophageal cancer
angioedema
head and neck cancer
allergic diseases
contact dermatitis
chronic rhinosinusitis
|
|
gptkbp:full_name
|
gptkb:Programmed_cell_death_protein_1
|
|
gptkbp:function
|
immune checkpoint
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PD-1
|
|
gptkbp:initiated_by
|
T cell activation
cytokine production
|
|
gptkbp:interacts_with
|
gptkb:PD-L2
gptkb:PD-L1
|
|
gptkbp:involved_in
|
cancer progression
therapeutic resistance
T cell exhaustion
|
|
gptkbp:is_expressed_in
|
gptkb:T_cells
B cells
|
|
gptkbp:is_found_in
|
gptkb:humans
mice
|
|
gptkbp:is_regulated_by
|
transcription factors
cytokines
|
|
gptkbp:is_targeted_at
|
anti-PD-1 therapy
|
|
gptkbp:location
|
cell membrane
|
|
gptkbp:promoter
|
gptkb:PDCD1
|
|
gptkbp:related_to
|
immune tolerance
immune evasion
|
|
gptkbp:role
|
tumor microenvironment
autoimmunity
chronic infection
|
|
gptkbp:bfsParent
|
gptkb:Libtayo
gptkb:Imfinzi
gptkb:Opdivo
|
|
gptkbp:bfsLayer
|
5
|