|
gptkbp:instanceOf
|
gptkb:immune_response
|
|
gptkbp:alsoKnownAs
|
Tregs
|
|
gptkbp:canBeInducedFrom
|
naive CD4+ T cells
|
|
gptkbp:developIn
|
gptkb:thymus
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:autoimmune_disease
gptkb:cancer
gptkb:allergy
|
|
gptkbp:expressedIn
|
gptkb:Helios
gptkb:FOXP3
gptkb:CTLA-4
gptkb:CD4
gptkb:LAG-3
gptkb:CD25
gptkb:GITR
gptkb:CD39
CD73
|
|
gptkbp:firstDescribed
|
1995
|
|
gptkbp:function
|
immune tolerance
suppression of immune response
|
|
gptkbp:inhibitedBy
|
autoimmunity
inflammatory response
|
|
gptkbp:marking
|
gptkb:FOXP3
gptkb:CD4
gptkb:CD25
CD127low
CD25high
|
|
gptkbp:proportionInBlood
|
5-10% of CD4+ T cells
|
|
gptkbp:recognizedBy
|
Sakaguchi et al.
|
|
gptkbp:regulates
|
gptkb:FOXP3
|
|
gptkbp:requires
|
IL-2 for survival
TGF-beta for induction
|
|
gptkbp:role
|
gptkb:allergy
autoimmune diseases
cancer immunology
transplant tolerance
|
|
gptkbp:secretes
|
gptkb:IL-10
gptkb:TGF-beta
|
|
gptkbp:subclassOf
|
gptkb:T_cells
|
|
gptkbp:suppressedBy
|
gptkb:natural_killer_cells
gptkb:B_cells
dendritic cells
effector T cells
|
|
gptkbp:targetOfDrug
|
gptkb:immunotherapy
autoimmune diseases
transplant rejection
|
|
gptkbp:type
|
induced Tregs (iTregs)
natural Tregs (nTregs)
|
|
gptkbp:bfsParent
|
gptkb:IL2
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
T regulatory cells
|