T regulatory cells

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf immune response
gptkbp:alsoKnownAs Tregs
gptkbp:canBeInducedFrom naive CD4+ T cells
gptkbp:developIn gptkb:thymus
gptkbp:dysregulationAssociatedWith gptkb:cancer
gptkb:allergy
autoimmune disease
gptkbp:expressedIn gptkb:Helios
gptkb:FOXP3
gptkb:CTLA-4
gptkb:CD4
gptkb:LAG-3
gptkb:CD25
gptkb:GITR
gptkb:CD39
CD73
gptkbp:firstDescribed 1995
gptkbp:function immune tolerance
suppression of immune response
https://www.w3.org/2000/01/rdf-schema#label T regulatory cells
gptkbp:inhibitedBy autoimmunity
inflammatory response
gptkbp:marking gptkb:FOXP3
gptkb:CD4
gptkb:CD25
CD127low
CD25high
gptkbp:proportionInBlood 5-10% of CD4+ T cells
gptkbp:recognizedBy Sakaguchi et al.
gptkbp:regulates gptkb:FOXP3
gptkbp:requires IL-2 for survival
TGF-beta for induction
gptkbp:role gptkb:allergy
autoimmune diseases
cancer immunology
transplant tolerance
gptkbp:secretes gptkb:IL-10
gptkb:TGF-beta
gptkbp:subclassOf gptkb:T_cells
gptkbp:suppressedBy gptkb:natural_killer_cells
gptkb:B_cells
dendritic cells
effector T cells
gptkbp:targetOfDrug immunotherapy
autoimmune diseases
transplant rejection
gptkbp:type induced Tregs (iTregs)
natural Tregs (nTregs)
gptkbp:bfsParent gptkb:IL2
gptkbp:bfsLayer 7