|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:alternativeName
|
gptkb:T_cell_growth_factor
|
|
gptkbp:approvedBy
|
metastatic melanoma
metastatic renal cell carcinoma
|
|
gptkbp:clinicalTrialPhase
|
immunotherapy
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:encodedBy
|
gptkb:IL2_gene
|
|
gptkbp:fullName
|
gptkb:Interleukin-2
|
|
gptkbp:function
|
activates natural killer cells
promotes proliferation of B cells
stimulates growth and differentiation of T cells
|
|
gptkbp:halfLife
|
7-10 minutes (in plasma)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL2
|
|
gptkbp:locatedOnChromosome
|
gptkb:4q27
|
|
gptkbp:molecularWeight
|
15.5 kDa
|
|
gptkbp:producedBy
|
activated T cells
|
|
gptkbp:promotion
|
cytotoxic T lymphocytes
NK cell cytotoxicity
|
|
gptkbp:recipient
|
gptkb:IL-2_receptor
|
|
gptkbp:regulates
|
gptkb:T_regulatory_cells
immune response
|
|
gptkbp:sideEffect
|
gptkb:capillary_leak_syndrome
fever
nausea
vomiting
fatigue
chills
hypotension
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:structure
|
four alpha-helix bundle
|
|
gptkbp:usedAs
|
immunotherapy agent
|
|
gptkbp:usedIn
|
HIV therapy research
autoimmune disease research
|
|
gptkbp:bfsParent
|
gptkb:EGR1
gptkb:Il-2
|
|
gptkbp:bfsLayer
|
6
|