|
gptkbp:instanceOf
|
gptkb:protein
immunotherapy
|
|
gptkbp:alternativeName
|
CD223
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:binds
|
gptkb:MHC_class_II_molecules
|
|
gptkbp:clinicalTrialPhase
|
ongoing
|
|
gptkbp:co-expressedWith
|
gptkb:CTLA-4
gptkb:PD-1
TIM-3
|
|
gptkbp:discoveredBy
|
Frederic Triebel
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodedBy
|
LAG3 gene
|
|
gptkbp:Entrez_Gene_ID
|
3902
ENSG00000089692
|
|
gptkbp:expressedIn
|
gptkb:NK_cells
gptkb:B_cells
gptkb:plasmacytoid_dendritic_cells
activated T cells
|
|
gptkbp:foundIn
|
humans
mice
|
|
gptkbp:fullName
|
Lymphocyte-activation gene 3
|
|
gptkbp:function
|
regulation of T cell function
inhibition of immune response
|
|
gptkbp:gene
|
LAG3
|
|
gptkbp:HGNC_ID
|
HGNC:6510
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LAG-3
|
|
gptkbp:inhibitedBy
|
T cell proliferation
cytokine secretion
|
|
gptkbp:length
|
525
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
|
|
gptkbp:modulatedBy
|
T cell exhaustion
immune checkpoint pathways
|
|
gptkbp:OMIM
|
153619
|
|
gptkbp:orthologIn
|
gptkb:CD4
|
|
gptkbp:regulates
|
immune tolerance
|
|
gptkbp:reviewedBy
|
gptkb:Nature_Reviews_Immunology
gptkb:Journal_of_Immunology
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:target
|
immunotherapy
monoclonal antibodies
IMP321
favezelimab
relatlimab
|
|
gptkbp:targetOfDrug
|
autoimmune disorders
leukemia
melanoma
solid tumors
|
|
gptkbp:UniProtID
|
P18627
|
|
gptkbp:bfsParent
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:bfsLayer
|
7
|