|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:TGFBR1
|
|
gptkbp:associatedWith
|
gptkb:Loeys-Dietz_syndrome
gptkb:hereditary_hemorrhagic_telangiectasia
|
|
gptkbp:binds
|
TGF-beta ligand
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodedBy
|
gptkb:TGFBR1_gene
|
|
gptkbp:formsComplexWith
|
gptkb:TGF-beta_type_II_receptor
|
|
gptkbp:function
|
signal transduction
serine/threonine kinase activity
|
|
gptkbp:gene
|
gptkb:TGFBR1
|
|
gptkbp:hasExtracellularDomain
|
yes
|
|
gptkbp:hasIntracellularDomain
|
yes
|
|
gptkbp:involvedIn
|
gptkb:TGF-beta_signaling_pathway
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:9q22
|
|
gptkbp:molecularWeight
|
~55 kDa
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
cancer susceptibility
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:phosphorylates
|
gptkb:SMAD2
gptkb:SMAD3
|
|
gptkbp:proteinFamily
|
gptkb:TGF-beta_receptor_family
|
|
gptkbp:regulates
|
gptkb:immune_response
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
P36897
|
|
gptkbp:bfsParent
|
gptkb:TGF-beta_receptor_family
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TGF-beta type I receptor
|