|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:DPC4
gptkb:SMAD4
|
|
gptkbp:associatedWith
|
gptkb:juvenile_polyposis_syndrome
colorectal cancer
pancreatic cancer
|
|
gptkbp:biologicalProcess
|
transcription factor
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
gptkb:SMAD4_protein
|
|
gptkbp:Entrez_Gene_ID
|
4089
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6770
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MADH4
|
|
gptkbp:interactsWith
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:TGFBR2
gptkb:TGFBR1
|
|
gptkbp:involvedIn
|
gptkb:TGF-beta_signaling_pathway
|
|
gptkbp:length
|
552 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:18q21.2
|
|
gptkbp:memberOf
|
gptkb:SMAD_family
|
|
gptkbp:molecularWeight
|
60 kDa
|
|
gptkbp:mutationAssociatedWith
|
tumor suppressor
loss of TGF-beta signaling
|
|
gptkbp:OMIM
|
600993
|
|
gptkbp:orthologInMouse
|
gptkb:Smad4
|
|
gptkbp:regulates
|
transcription of target genes
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q13485
|
|
gptkbp:bfsParent
|
gptkb:SMAD4
|
|
gptkbp:bfsLayer
|
6
|