ibrutinib

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:drug
Bruton tyrosine kinase inhibitor
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
2013
gptkbp:ATCCode L01EL01
gptkbp:brand gptkb:Imbruvica
gptkbp:CASNumber 936563-96-1
gptkbp:category protease inhibitor
antineoplastic agent
gptkbp:chemicalClass aminopyrimidine
gptkbp:contraindication hypersensitivity to ibrutinib
gptkbp:cost high
gptkbp:developedBy gptkb:Janssen_Biotech
gptkb:Pharmacyclics
gptkbp:discoveredBy gptkb:Pharmacyclics
gptkbp:eliminationHalfLife 4-6 hours
gptkbp:excretion urine
feces
gptkbp:form gptkb:tablet
capsule
gptkbp:hasMolecularFormula C25H24N6O2
gptkbp:hasSMILES CC1=CC(=C(N=C1)N2C=NC3=C2N=CN=C3C4=CC=CC=C4)C(=O)NC5=CC=CC=C5O
https://www.w3.org/2000/01/rdf-schema#label ibrutinib
gptkbp:interactsWith CYP3A4 inhibitors
CYP3A4 inducers
gptkbp:KEGGID gptkb:D09950
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits Bruton tyrosine kinase
gptkbp:metabolism liver (CYP3A4)
gptkbp:patent 2006
gptkbp:pregnancyCategory D (US)
gptkbp:pregnancyWarning may cause fetal harm
gptkbp:PubChem_CID gptkb:CHEMBL1873475
gptkb:DB09053
24821094
26333216
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:atrial_fibrillation
diarrhea
bleeding
infection
hypertension
gptkbp:UNII IMT5049V5F9
gptkbp:usedFor gptkb:mantle_cell_lymphoma
gptkb:Waldenström's_macroglobulinemia
gptkb:chronic_graft_versus_host_disease
gptkb:marginal_zone_lymphoma
chronic lymphocytic leukemia
gptkbp:bfsParent gptkb:Waldenström's_macroglobulinemia
gptkbp:bfsLayer 6