|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:NEF
Negative factor
|
|
gptkbp:disrupts
|
T cell activation
antigen presentation
|
|
gptkbp:encodedBy
|
gptkb:nef_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:4932_(HIV-1_nef_gene)
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:foundIn
|
gptkb:HIV-1
gptkb:HIV-2
|
|
gptkbp:function
|
downregulation of CD4
downregulation of MHC I
enhancement of viral infectivity
modulation of T cell signaling
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Nef (protein)
|
|
gptkbp:improves
|
viral particle release
|
|
gptkbp:inhibitedBy
|
apoptosis in infected cells
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:AP-2_complex
gptkb:PACS-1
gptkb:Src_family_kinases
|
|
gptkbp:length
|
206 amino acids (HIV-1 Nef)
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
27-35 kDa
|
|
gptkbp:postTranslationalModification
|
phosphorylation
myristoylation
|
|
gptkbp:role
|
immune evasion
HIV pathogenesis
viral replication
|
|
gptkbp:structure
|
core domain with alpha helices and beta sheets
myristoylated N-terminus
|
|
gptkbp:UniProtID
|
gptkb:P12497_(HIV-1_Nef)
|
|
gptkbp:bfsParent
|
gptkb:Nef
|
|
gptkbp:bfsLayer
|
6
|