Signal transducer and activator of transcription 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:STAT1
gptkbp:activatedBy	gptkb:interferon_gamma gptkb:interleukin-6 gptkb:interferon_alpha
gptkbp:alternativeSplicing	produces multiple isoforms
gptkbp:associatedWith	gptkb:immunodeficiency autoimmune diseases
gptkbp:biologicalProcess	DNA binding protein dimerization
gptkbp:cellularComponent	gptkb:nucleus gptkb:cytoplasm
gptkbp:discoveredBy	gptkb:James_E._Darnell
gptkbp:encodedBy	gptkb:STAT1_gene
gptkbp:Entrez_Gene_ID	6772
gptkbp:function	gptkb:transcription_factor signal transduction
gptkbp:HGNC_ID	11362
gptkbp:inhibitedBy	gptkb:SOCS1 gptkb:PIAS1
gptkbp:interactsWith	gptkb:JAK2 gptkb:CBP/p300 gptkb:JAK1 gptkb:STAT2 gptkb:IFNGR1 gptkb:IRF9
gptkbp:involvedIn	gptkb:JAK-STAT_signaling_pathway interferon signaling pathway
gptkbp:length	750 amino acids (canonical isoform)
gptkbp:locatedOnChromosome	gptkb:2q32.2
gptkbp:molecularWeight	87 kDa
gptkbp:mutationAssociatedWith	gptkb:STAT1_deficiency STAT1 gain-of-function disease
gptkbp:OMIM	600555
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:PDB	gptkb:1YVL
gptkbp:phosphorylates	gptkb:Ser727 Tyr701
gptkbp:postTranslationalModification	phosphorylation
gptkbp:regulates	gene expression
gptkbp:reviewedBy	gptkb:GeneCards gptkb:NCBI_Gene gptkb:UniProt
gptkbp:UniProtID	gptkb:P42224
gptkbp:bfsParent	gptkb:STAT1
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Signal transducer and activator of transcription 1