Signal transducer and activator of transcription 1

URI: https://gptkb.org/entity/Signal_transducer_and_activator_of_transcription_1
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:STAT1
gptkbp:activatedBy gptkb:interferon_gamma
gptkb:interleukin-6
interferon alpha
gptkbp:alternativeSplicing produces multiple isoforms
gptkbp:associatedWith autoimmune diseases
immunodeficiency
gptkbp:biologicalProcess DNA binding
protein dimerization
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:discoveredBy gptkb:James_E._Darnell
gptkbp:encodedBy gptkb:STAT1_gene
gptkbp:Entrez_Gene_ID 6772
gptkbp:function signal transduction
transcription factor
gptkbp:HGNC_ID 11362
https://www.w3.org/2000/01/rdf-schema#label Signal transducer and activator of transcription 1
gptkbp:inhibitedBy gptkb:SOCS1
gptkb:PIAS1
gptkbp:interactsWith gptkb:JAK2
gptkb:CBP/p300
gptkb:JAK1
gptkb:STAT2
gptkb:IFNGR1
gptkb:IRF9
gptkbp:involvedIn gptkb:JAK-STAT_signaling_pathway
interferon signaling pathway
gptkbp:length 750 amino acids (canonical isoform)
gptkbp:locatedOnChromosome gptkb:2q32.2
gptkbp:molecularWeight 87 kDa
gptkbp:mutationAssociatedWith gptkb:STAT1_deficiency
STAT1 gain-of-function disease
gptkbp:OMIM 600555
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB gptkb:1YVL
gptkbp:phosphorylates gptkb:Ser727
Tyr701
gptkbp:postTranslationalModification phosphorylation
gptkbp:regulates gene expression
gptkbp:reviewedBy gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
gptkbp:UniProtID gptkb:P42224
gptkbp:bfsParent gptkb:STAT1
gptkbp:bfsLayer 7