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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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E3 SUMO-protein ligase PIAS1
Drosophila protein inhibitor of activated STAT homolog
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gptkbp:associatedWith
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gptkb:cancer
autoimmune diseases
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gptkbp:biologicalProcess
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DNA repair
regulation of transcription
innate immune response
protein sumoylation
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gptkbp:discoveredBy
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1997
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gptkbp:domain
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gptkb:PINIT_domain
gptkb:SAP_domain
SIM (SUMO-interacting motif)
SP-RING-type zinc finger
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gptkbp:encodedBy
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PIAS1 gene
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gptkbp:Entrez_Gene_ID
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ENSG00000185551
GC15M075282
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gptkbp:expressedIn
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many tissues
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gptkbp:fullName
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Protein Inhibitor of Activated STAT 1
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gptkbp:function
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transcriptional coregulator
E3 SUMO-protein ligase
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gptkbp:gene
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gptkb:PIAS1
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gptkbp:HGNC_ID
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HGNC:17076
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gptkbp:highestExpression
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gptkb:testis
gptkb:thymus
spleen
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https://www.w3.org/2000/01/rdf-schema#label
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PIAS1
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gptkbp:interactsWith
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gptkb:SMAD3
gptkb:STAT1
gptkb:Androgen_receptor
gptkb:p53
gptkb:DNMT3A
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gptkbp:locatedOnChromosome
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15q23
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gptkbp:molecularWeight
|
71 kDa
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gptkbp:OMIM
|
603566
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
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mouse Pias1
rat Pias1
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gptkbp:pathway
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gptkb:JAK-STAT_signaling_pathway
p53 signaling pathway
androgen receptor signaling pathway
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gptkbp:postTranslationalModification
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phosphorylation
sumoylation
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gptkbp:RefSeq
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NM_016166
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gptkbp:regulates
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p53-mediated transcription
STAT1 activity
androgen receptor activity
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gptkbp:subcellularLocation
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gptkb:nucleus
gptkb:cytoplasm
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gptkbp:UniProtID
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O75925
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gptkbp:bfsParent
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gptkb:PIAS_proteins
gptkb:Signal_transducer_and_activator_of_transcription_1
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gptkbp:bfsLayer
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8
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