Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alias |
gptkb:JAB
SOCS-1 SSI-1 STAT-induced STAT inhibitor 1 TIP-3 |
| gptkbp:associatedWith |
gptkb:cancer
type 1 diabetes autoimmune diseases |
| gptkbp:discoveredBy |
Yoshimura et al.
|
| gptkbp:discoveredIn |
1997
|
| gptkbp:domain |
gptkb:SOCS_box
SH2 domain |
| gptkbp:encodes |
Suppressor of cytokine signaling 1 protein
|
| gptkbp:Entrez_Gene_ID |
8651
ENSG00000185338 |
| gptkbp:expressedIn |
gptkb:cancer
gptkb:kidney liver spleen hematopoietic cells |
| gptkbp:fullName |
Suppressor of cytokine signaling 1
|
| gptkbp:function |
negative regulation of cytokine signaling
inhibition of JAK/STAT signaling pathway |
| gptkbp:HGNC_ID |
HGNC:19382
|
| https://www.w3.org/2000/01/rdf-schema#label |
SOCS1
|
| gptkbp:inhibitedBy |
gptkb:JAK2
gptkb:JAK1 gptkb:TYK2 STAT signaling |
| gptkbp:length |
211 amino acids
|
| gptkbp:locatedOnChromosome |
16
|
| gptkbp:location |
gptkb:16p13.13
|
| gptkbp:mutationAssociatedWith |
gptkb:systemic_lupus_erythematosus
leukemia hepatocellular carcinoma |
| gptkbp:orthologIn |
mouse Socs1
|
| gptkbp:regulates |
apoptosis
cell proliferation immune response T cell activation inflammatory response insulin signaling growth hormone signaling prolactin signaling macrophage activation erythropoietin signaling leptin signaling IL-6 signaling IL-2 signaling interferon gamma signaling |
| gptkbp:UniProtID |
O15524
|
| gptkbp:bfsParent |
gptkb:SOCS
gptkb:SOCS_family gptkb:SOCS_proteins gptkb:Cish_(mouse_gene) |
| gptkbp:bfsLayer |
7
|