|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:JAB
SOCS-1
SSI-1
STAT-induced STAT inhibitor 1
TIP-3
|
|
gptkbp:associatedWith
|
gptkb:cancer
type 1 diabetes
autoimmune diseases
|
|
gptkbp:discoveredBy
|
Yoshimura et al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:domain
|
gptkb:SOCS_box
SH2 domain
|
|
gptkbp:encodes
|
Suppressor of cytokine signaling 1 protein
|
|
gptkbp:Entrez_Gene_ID
|
8651
ENSG00000185338
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
liver
spleen
hematopoietic cells
|
|
gptkbp:fullName
|
Suppressor of cytokine signaling 1
|
|
gptkbp:function
|
negative regulation of cytokine signaling
inhibition of JAK/STAT signaling pathway
|
|
gptkbp:HGNC_ID
|
HGNC:19382
|
|
gptkbp:inhibitedBy
|
gptkb:JAK2
gptkb:JAK1
gptkb:TYK2
STAT signaling
|
|
gptkbp:length
|
211 amino acids
|
|
gptkbp:locatedOnChromosome
|
16
|
|
gptkbp:location
|
gptkb:16p13.13
|
|
gptkbp:mutationAssociatedWith
|
gptkb:leukemia
gptkb:systemic_lupus_erythematosus
hepatocellular carcinoma
|
|
gptkbp:orthologIn
|
mouse Socs1
|
|
gptkbp:regulates
|
gptkb:immune_response
apoptosis
cell proliferation
T cell activation
inflammatory response
insulin signaling
growth hormone signaling
prolactin signaling
macrophage activation
erythropoietin signaling
leptin signaling
IL-6 signaling
IL-2 signaling
interferon gamma signaling
|
|
gptkbp:UniProtID
|
O15524
|
|
gptkbp:bfsParent
|
gptkb:SOCS
gptkb:SOCS_family
gptkb:SOCS_proteins
gptkb:Cish_(mouse_gene)
gptkb:Signal_transducer_and_activator_of_transcription_1
gptkb:miR-155
gptkb:PIM1_proto-oncogene,_serine/threonine_kinase
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SOCS1
|