|
gptkbp:instanceOf
|
gptkb:protein
cytokine
|
|
gptkbp:associatedWith
|
gptkb:cancer
infectious diseases
autoimmune diseases
|
|
gptkbp:discoveredBy
|
E. F. Wheelock
R. H. Y. Wang
|
|
gptkbp:discoveredIn
|
1965
|
|
gptkbp:encodedBy
|
gptkb:IFNG_gene
|
|
gptkbp:Entrez_Gene_ID
|
3458
|
|
gptkbp:function
|
immune response regulation
antiviral activity
activation of macrophages
antitumor activity
|
|
gptkbp:halfLife
|
5-10 minutes (in plasma)
|
|
gptkbp:hasApprovedDrug
|
interferon gamma-1b
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interferon gamma
|
|
gptkbp:inducedBy
|
antigen presentation
|
|
gptkbp:inhibitedBy
|
Th2 immune response
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12q15
|
|
gptkbp:MIM
|
147570
|
|
gptkbp:molecularWeight
|
16.8 kDa (monomer)
|
|
gptkbp:producedBy
|
gptkb:natural_killer_cells
gptkb:T_cells
|
|
gptkbp:promotion
|
gptkb:Th1_immune_response
|
|
gptkbp:recipient
|
interferon gamma receptor
|
|
gptkbp:regulates
|
MHC class II expression
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
P01579
|
|
gptkbp:usedFor
|
gptkb:chronic_granulomatous_disease
severe malignant osteopetrosis
|
|
gptkbp:bfsParent
|
gptkb:PD-L1_expression
|
|
gptkbp:bfsLayer
|
6
|