Signal Transducers and Activators of Transcription (STATs)
GPTKB entity
Statements (36)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:STATs
|
| gptkbp:activatedBy |
cytokines
growth factors |
| gptkbp:associatedWith |
gptkb:cancer
autoimmune diseases inflammatory diseases |
| gptkbp:binds |
gptkb:gene
|
| gptkbp:component |
gptkb:JAK-STAT_signaling_pathway
|
| gptkbp:discoveredBy |
gptkb:James_E._Darnell
|
| gptkbp:discoveredIn |
1994
|
| gptkbp:domain |
SH2 domain
DNA-binding domain transactivation domain |
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
signal transduction
transcription factor |
| gptkbp:hasMember |
gptkb:STAT1
gptkb:STAT2 gptkb:STAT4 gptkb:STAT5A gptkb:STAT5B gptkb:STAT6 gptkb:STAT3 |
| https://www.w3.org/2000/01/rdf-schema#label |
Signal Transducers and Activators of Transcription (STATs)
|
| gptkbp:phosphorylates |
Janus kinases (JAKs)
|
| gptkbp:regulates |
gene expression
|
| gptkbp:role |
apoptosis
differentiation cell growth immune response oncogenesis |
| gptkbp:translocatesTo |
cell nucleus
|
| gptkbp:bfsParent |
gptkb:STAT_pathway
gptkb:JAK/STAT_signaling_pathway |
| gptkbp:bfsLayer |
7
|