STAT transcription factors

URI: https://gptkb.org/entity/STAT_transcription_factors
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy gptkb:interleukins
cytokines
growth factors
tyrosine kinases
interferons
gptkbp:binds gptkb:gene
GAS elements
gptkbp:database gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
gptkbp:discoveredBy gptkb:James_E._Darnell
gptkbp:firstDescribed 1994
gptkbp:foundIn vertebrates
some invertebrates
gptkbp:fullName Signal Transducer and Activator of Transcription
gptkbp:function signal transduction
transcription factor
gene expression regulation
https://www.w3.org/2000/01/rdf-schema#label STAT transcription factors
gptkbp:locatedOnChromosome varies by STAT member
gptkbp:mechanismOfAction dimerization
phosphorylation
nuclear translocation
gptkbp:member gptkb:STAT1
gptkb:STAT2
gptkb:STAT4
gptkb:STAT5A
gptkb:STAT5B
gptkb:STAT6
gptkb:STAT3
gptkbp:pathway gptkb:JAK-STAT_pathway
gptkbp:relatedTo apoptosis
cell growth
immune response
oncogenesis
hematopoiesis
gptkbp:significance gptkb:cancer
autoimmune diseases
inflammatory diseases
gptkbp:structure SH2 domain
DNA-binding domain
transactivation domain
coiled-coil domain
gptkbp:target biologics
small molecule inhibitors
therapeutic drugs
gptkbp:bfsParent gptkb:SOCS
gptkb:SOCS_proteins
gptkbp:bfsLayer 7