|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:extracellular_SOD
gptkb:EC-SOD
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
amyotrophic lateral sclerosis
asthma
|
|
gptkbp:cofactor
|
copper
zinc
|
|
gptkbp:discoveredBy
|
gptkb:Marklund_SL
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000109610
6649
|
|
gptkbp:enzymeCommissionNumber
|
1.15.1.1
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
heart
pancreas
blood vessels
|
|
gptkbp:fullName
|
gptkb:Extracellular_superoxide_dismutase_[Cu-Zn]
|
|
gptkbp:function
|
catalyzes the dismutation of superoxide radicals
|
|
gptkbp:gene
|
gptkb:SOD3
|
|
gptkbp:GO_term
|
gptkb:GO:0004784
gptkb:GO:0005615
GO:0006950
|
|
gptkbp:HGNC_ID
|
11181
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SOD3
|
|
gptkbp:locatedOnChromosome
|
4
|
|
gptkbp:location
|
extracellular space
4p15.3-p15.1
|
|
gptkbp:molecularWeight
|
30 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased oxidative stress
vascular dysfunction
|
|
gptkbp:OMIM
|
185490
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Sod3
|
|
gptkbp:pathway
|
oxidative stress response
reactive oxygen species detoxification
|
|
gptkbp:PDB
|
gptkb:1PU0
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic processing
|
|
gptkbp:proteinFamily
|
gptkb:superoxide_dismutase_family
|
|
gptkbp:regulates
|
downregulated in diabetes
upregulated by oxidative stress
|
|
gptkbp:sequence
|
240 amino acids
|
|
gptkbp:subunit
|
homotetramer
|
|
gptkbp:UniProtID
|
P08294
|
|
gptkbp:bfsParent
|
gptkb:SOD
|
|
gptkbp:bfsLayer
|
6
|