Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:amyotrophic_lateral_sclerosis
|
| gptkbp:code |
superoxide dismutase 1
|
| gptkbp:discovered_by |
John E. Landers
|
| gptkbp:form |
SOD1 A
SOD1 B |
| gptkbp:genetic_studies |
causes familial ALS
|
| gptkbp:has_role |
antioxidant defense
|
| gptkbp:has_variants |
SOD1 A4 V
SOD1 E100 G SOD1 G93 A SOD1 H46 R |
| https://www.w3.org/2000/01/rdf-schema#label |
SOD1
|
| gptkbp:interacts_with |
copper ions
|
| gptkbp:involved_in |
oxidative stress response
|
| gptkbp:is_associated_with |
cognitive decline
respiratory failure muscle weakness |
| gptkbp:is_essential_for |
cellular homeostasis
|
| gptkbp:is_expressed_in |
gptkb:Brain
motor neurons spinal cord |
| gptkbp:is_involved_in |
biomarker discovery
cell signaling cellular metabolism cellular stress response clinical trials genetic studies mitochondrial function therapeutic interventions neuroinflammation cellular aging neuroprotection cellular signaling pathways neurodegeneration therapeutic targets cellular repair mechanisms neuroprotective strategies protein homeostasis diagnostic development protein misfolding cellular apoptosis protein aggregation apoptotic pathways neuron survival redox signaling |
| gptkbp:is_linked_to |
inflammation
oxidative damage |
| gptkbp:is_located_in |
cytosol
|
| gptkbp:is_part_of |
antioxidant enzymes
superoxide dismutase family |
| gptkbp:is_studied_for |
drug development
|
| gptkbp:is_studied_in |
ALS research
|
| gptkbp:is_targeted_at |
small molecules
|
| gptkbp:located_in |
chromosome 21
|
| gptkbp:related_to |
gptkb:neurodegenerative_diseases
|
| gptkbp:targets |
gptkb:gene_therapy
|
| gptkbp:bfsParent |
gptkb:Motor_Neurone_Disease
gptkb:superoxide_dismutase_1_protein |
| gptkbp:bfsLayer |
6
|