|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activity
|
inhibition of cytochrome c reduction
|
|
gptkbp:alternativeName
|
gptkb:superoxide_dismutase_1
gptkb:SOD_(Cu-Zn)
gptkb:SOD1
|
|
gptkbp:associatedWith
|
amyotrophic lateral sclerosis
|
|
gptkbp:cellularRole
|
antioxidant defense
|
|
gptkbp:cofactor
|
copper
zinc
|
|
gptkbp:discoveredBy
|
gptkb:Irwin_Fridovich
gptkb:Joe_M._McCord
|
|
gptkbp:discoveredIn
|
1969
|
|
gptkbp:EC_number
|
1.15.1.1
|
|
gptkbp:Entrez_Gene_ID
|
6647 (human SOD1)
|
|
gptkbp:EnzymeClass
|
oxidoreductase
|
|
gptkbp:foundIn
|
gptkb:cytoplasm
extracellular space
mitochondria (in some organisms)
|
|
gptkbp:fullName
|
gptkb:Copper-zinc_superoxide_dismutase
|
|
gptkbp:function
|
catalyzes the dismutation of superoxide radicals
|
|
gptkbp:gene
|
gptkb:SOD1
|
|
gptkbp:GO_term
|
GO:0004784 (superoxide dismutase activity)
GO:0005737 (cytoplasm)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cu,Zn-SOD
|
|
gptkbp:inhibitedBy
|
gptkb:diethyldithiocarbamate
|
|
gptkbp:isoenzyme
|
gptkb:SOD2_(Mn-SOD)
gptkb:SOD3_(EC-SOD)
|
|
gptkbp:locale
|
mainly cytosolic
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_21_(in_humans)
|
|
gptkbp:medicalUse
|
biomarker for oxidative stress
|
|
gptkbp:molecularWeight
|
~32 kDa (dimer)
|
|
gptkbp:mutationAssociatedWith
|
linked to familial ALS
missense mutations
|
|
gptkbp:OMIM
|
147450
|
|
gptkbp:organism
|
humans
many eukaryotes
|
|
gptkbp:pathway
|
reactive oxygen species detoxification
|
|
gptkbp:PDB
|
gptkb:1HL5
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
glutathionylation
|
|
gptkbp:product
|
hydrogen peroxide (H2O2)
oxygen (O2)
|
|
gptkbp:proteinFamily
|
gptkb:SOD_Cu_family
|
|
gptkbp:significance
|
mutations cause neurodegeneration
|
|
gptkbp:stable
|
high thermal stability
|
|
gptkbp:structure
|
homodimer
beta-barrel fold
|
|
gptkbp:substrate
|
superoxide anion (O2−)
|
|
gptkbp:tissue_specificity
|
ubiquitous in tissues
|
|
gptkbp:UniProtID
|
gptkb:P00441
|
|
gptkbp:bfsParent
|
gptkb:SOD
|
|
gptkbp:bfsLayer
|
6
|