|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:SOD3
gptkb:EC-SOD
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
gptkb:pneumonia
oxidative stress
|
|
gptkbp:binds
|
gptkb:collagen
gptkb:heparin
gptkb:extracellular_matrix
|
|
gptkbp:cofactor
|
copper
zinc
|
|
gptkbp:discoveredBy
|
1990
|
|
gptkbp:EC_number
|
1.15.1.1
|
|
gptkbp:Entrez_Gene_ID
|
6649
|
|
gptkbp:fullName
|
gptkb:extracellular_superoxide_dismutase
|
|
gptkbp:function
|
catalyzes dismutation of superoxide radicals
|
|
gptkbp:gene
|
gptkb:SOD3
|
|
gptkbp:inhibitedBy
|
gptkb:diethyldithiocarbamate
hydrogen peroxide
cyanide
|
|
gptkbp:locatedOnChromosome
|
4p15.3-p15.1
|
|
gptkbp:location
|
extracellular space
|
|
gptkbp:molecularWeight
|
~30 kDa
|
|
gptkbp:mutationAssociatedWith
|
altered cardiovascular risk
increased susceptibility to oxidative damage
|
|
gptkbp:OMIM
|
185490
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
gptkb:right
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic processing
|
|
gptkbp:product
|
hydrogen peroxide
oxygen
|
|
gptkbp:sequence_length_(human)
|
240 amino acids
|
|
gptkbp:significance
|
biomarker for oxidative stress
therapeutic target
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:substrate
|
gptkb:superoxide_anion
|
|
gptkbp:tissue_distribution
|
gptkb:cancer
gptkb:plasma
gptkb:kidney
brain
heart
liver
pancreas
blood vessels
|
|
gptkbp:UniProtID
|
P08294
|
|
gptkbp:bfsParent
|
gptkb:SOD
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
extracellular SOD
|