|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:SOD
gptkb:superoxide_oxidoreductase
|
|
gptkbp:associatedWith
|
gptkb:Down_syndrome
gptkb:cancer
gptkb:ischemia-reperfusion_injury
amyotrophic lateral sclerosis
|
|
gptkbp:biologicalProcess
|
oxidative stress response
|
|
gptkbp:CASNumber
|
9054-89-1
|
|
gptkbp:chromosome_location_(human_SOD1)
|
gptkb:21q22.11
|
|
gptkbp:chromosome_location_(human_SOD2)
|
6q25.3
|
|
gptkbp:chromosome_location_(human_SOD3)
|
4p15.3-p15.1
|
|
gptkbp:cofactor
|
copper
iron
zinc
manganese
|
|
gptkbp:discoveredBy
|
gptkb:Joe_McCord
gptkb:Irwin_Fridovich
|
|
gptkbp:discoveredIn
|
1969
|
|
gptkbp:EC_number
|
1.15.1.1
|
|
gptkbp:enzymeClassification
|
oxidoreductase
|
|
gptkbp:foundIn
|
almost all aerobic organisms
|
|
gptkbp:function
|
catalyzes the dismutation of superoxide into oxygen and hydrogen peroxide
|
|
gptkbp:gene
|
gptkb:SOD2
gptkb:SOD3
gptkb:SOD1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
superoxide dismutase
|
|
gptkbp:inhibitedBy
|
gptkb:diethyldithiocarbamate
cyanide
|
|
gptkbp:medical_application
|
potential anti-inflammatory agent
potential neuroprotective agent
|
|
gptkbp:molecularWeight
|
~32 kDa (SOD1 dimer)
|
|
gptkbp:PDB
|
yes
|
|
gptkbp:presentIn
|
gptkb:Bacteria
animals
humans
plants
|
|
gptkbp:product
|
hydrogen peroxide
oxygen
|
|
gptkbp:role
|
mutations in SOD1 cause familial amyotrophic lateral sclerosis
|
|
gptkbp:structure
|
glycosylated (SOD3)
homodimer (SOD1)
homotetramer (SOD2)
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
mitochondria
extracellular space
|
|
gptkbp:substrate
|
gptkb:superoxide_anion
|
|
gptkbp:UniProtID
|
gptkb:P00441
|
|
gptkbp:used_in_therapy
|
antioxidant therapy research
|
|
gptkbp:bfsParent
|
gptkb:SOD
|
|
gptkbp:bfsLayer
|
6
|