Suppressor of Cytokine Signaling proteins

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:SOCS_proteins
gptkbp:discoveredBy	gptkb:Nicos_Nicola Douglas Hilton
gptkbp:domain	gptkb:SOCS_box SH2 domain
gptkbp:expressedIn	various tissues
gptkbp:firstDescribed	1997
gptkbp:function	negative regulation of cytokine signaling
https://www.w3.org/2000/01/rdf-schema#label	Suppressor of Cytokine Signaling proteins
gptkbp:involves	gptkb:cancer autoimmune diseases inflammatory diseases immune regulation
gptkbp:mechanismOfAction	targeting proteins for ubiquitination and degradation inhibition of JAK kinases
gptkbp:member	gptkb:SOCS1 gptkb:SOCS2 gptkb:SOCS3 gptkb:SOCS4 gptkb:SOCS5 gptkb:SOCS6 gptkb:SOCS7 gptkb:CIS_(Cytokine_Inducible_SH2-containing_protein)
gptkbp:orthologIn	gptkb:fish birds mammals
gptkbp:proteinFamily	gptkb:SOCS_gene_family
gptkbp:regulates	gptkb:JAK-STAT_signaling_pathway cytokine receptor signaling
gptkbp:relatedTo	gptkb:STAT_proteins gptkb:JAK_kinases ubiquitin-proteasome system Cytokine signaling
gptkbp:bfsParent	gptkb:SOCS_proteins
gptkbp:bfsLayer	7