bone morphogenetic proteins

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:BMPs
gptkbp:approvedBy	FDA (for some BMPs)
gptkbp:binds	serine/threonine kinase receptors
gptkbp:category	cytokines growth factors morphogens
gptkbp:discoveredBy	gptkb:Marshall_Urist
gptkbp:encodedBy	BMP genes
gptkbp:enemyOf	gptkb:chordin gptkb:follistatin gremlin noggin
gptkbp:example	gptkb:BMP9 gptkb:BMP2 gptkb:BMP4 gptkb:BMP7
gptkbp:firstDescribed	1965
gptkbp:function	induce bone and cartilage formation
https://www.w3.org/2000/01/rdf-schema#label	bone morphogenetic proteins
gptkbp:involvedIn	embryonic development organogenesis skeletal development
gptkbp:locatedOnChromosome	chromosome 14 (BMP4) chromosome 2 (BMP10) chromosome 20 (BMP2, BMP7)
gptkbp:medicalUse	recombinant human BMPs
gptkbp:orthologIn	gptkb:Drosophila_decapentaplegic_(dpp) gptkb:zebrafish_bmp2b
gptkbp:pathway	gptkb:SMAD_pathway
gptkbp:producedBy	chondrocytes osteoblasts
gptkbp:recipient	gptkb:BMPR1A gptkb:BMPR1B gptkb:BMPR2
gptkbp:regulates	apoptosis differentiation cell growth
gptkbp:relatedTo	gptkb:fibrodysplasia_ossificans_progressiva cartilage repair osteogenesis
gptkbp:sideEffect	inflammation nerve injury ectopic bone formation
gptkbp:structure	dimeric proteins
gptkbp:superfamily	gptkb:transforming_growth_factor_beta_superfamily
gptkbp:usedIn	orthopedic surgery spinal fusion bone repair
gptkbp:bfsParent	gptkb:GDF2
gptkbp:bfsLayer	6