Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:SGK
gptkb:SGK1_HUMAN |
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:cancer
gptkb:diabetes_mellitus hypertension |
| gptkbp:biologicalProcess |
regulation of apoptosis
protein serine/threonine kinase activity cellular response to stress regulation of cell volume regulation of potassium ion transport regulation of sodium ion transport |
| gptkbp:chromosomeArm |
6q23.2
|
| gptkbp:discoveredIn |
1993
|
| gptkbp:encodes |
SGK1 protein
|
| gptkbp:Entrez_Gene_ID |
gptkb:ENSG00000118515
6446 |
| gptkbp:expressedIn |
high in colon
high in heart high in kidney high in liver high in brain widely expressed in human tissues high in pancreas |
| gptkbp:fullName |
gptkb:serum/glucocorticoid_regulated_kinase_1
|
| gptkbp:function |
cell proliferation
cell survival regulation of ion channels response to stress |
| gptkbp:HGNC_ID |
10899
|
| https://www.w3.org/2000/01/rdf-schema#label |
SGK1 gene
|
| gptkbp:locatedOnChromosome |
6
|
| gptkbp:location |
gptkb:cell_membrane
gptkb:nucleus gptkb:cytoplasm |
| gptkbp:mutationAssociatedWith |
implicated in cancer progression
associated with salt-sensitive hypertension implicated in metabolic syndrome |
| gptkbp:OMIM |
602958
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
gptkb:mouse_Sgk1
gptkb:rat_Sgk1 |
| gptkbp:pathway |
gptkb:PI3K-Akt_signaling_pathway
insulin signaling pathway |
| gptkbp:protein_kinase_family |
gptkb:AGC_protein_kinase_family
|
| gptkbp:regulates |
regulated by insulin
regulated by PI3K signaling regulated by mTORC2 regulated by serum and glucocorticoids upregulated by cell stress upregulated by glucocorticoids upregulated by serum |
| gptkbp:UniProtID |
gptkb:O00141
|
| gptkbp:bfsParent |
gptkb:SGK1
|
| gptkbp:bfsLayer |
7
|