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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:SGK
Serum/glucocorticoid-regulated kinase 1
|
|
gptkbp:alternativeSplicing
|
Yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Diabetes_mellitus
Hypertension
|
|
gptkbp:biologicalProcess
|
cellular response to stress
regulation of ion transport
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
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gptkbp:enzymeClassification
|
EC 2.7.11.1
|
|
gptkbp:fullName
|
Serine/threonine-protein kinase Sgk1
|
|
gptkbp:function
|
Regulates ion channels, transporters, and transcription factors
|
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gptkbp:gene
|
gptkb:SGK1
|
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gptkbp:goMolecularFunction
|
protein serine/threonine kinase activity
|
|
gptkbp:hasIsoform
|
2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SGK1 HUMAN
|
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gptkbp:inducedBy
|
gptkb:Serum
Cellular stress
Glucocorticoids
|
|
gptkbp:inhibitedBy
|
Inhibited by GSK650394
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:FOXO3
gptkb:GSK3B
gptkb:ENaC
gptkb:NEDD4L
|
|
gptkbp:length
|
431 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:6q23
|
|
gptkbp:molecularWeight
|
48 kDa
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
SGK1_MOUSE
SGK1_RAT
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
gptkb:Insulin_signaling_pathway
|
|
gptkbp:PDB
|
2R5T
3HDM
|
|
gptkbp:phosphorylates
|
Activated by PDK1
Ser422
Thr256
|
|
gptkbp:regulates
|
Induced by serum and glucocorticoids
|
|
gptkbp:sequenceStatus
|
Complete
|
|
gptkbp:subcellularLocation
|
gptkb:Nucleus
gptkb:Cell_membrane
gptkb:Cytoplasm
|
|
gptkbp:tissue_specificity
|
Widely expressed
|
|
gptkbp:UniProtID
|
gptkb:O00141
|
|
gptkbp:uniprotReviewed
|
Yes
|
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gptkbp:bfsParent
|
gptkb:SGK1
|
|
gptkbp:bfsLayer
|
7
|