Receptor Tyrosine Kinases

URI: https://gptkb.org/entity/Receptor_Tyrosine_Kinases
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy ligand binding
gptkbp:alternativeName gptkb:RTK
receptor protein-tyrosine kinase
gptkbp:catalyzes phosphorylation of tyrosine residues
gptkbp:compatibleWith prokaryotes
gptkbp:contains transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
gptkbp:discoveredBy gptkb:Stanley_Cohen
gptkbp:discoveredIn 1970s
gptkbp:downstreamOf gptkb:MAPK_pathway
gptkb:PLCĪ³_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
gptkbp:example gptkb:EGFR
gptkb:FGFR
gptkb:Insulin_receptor
gptkb:PDGFR
gptkb:VEGFR
gptkbp:foundIn animals
humans
plants
gptkbp:function cell differentiation
signal transduction
cell growth regulation
cell survival regulation
cell metabolism regulation
https://www.w3.org/2000/01/rdf-schema#label Receptor Tyrosine Kinases
gptkbp:inhibitedBy monoclonal antibodies
tyrosine kinase inhibitors
gptkbp:involves gptkb:cancer
gptkb:diabetes
developmental disorders
gptkbp:location gptkb:cell_membrane
gptkbp:mechanismOfAction autophosphorylation
dimerization upon ligand binding
gptkbp:mutationAssociatedWith drug resistance
oncogenesis
gptkbp:numberOfGenes 58
gptkbp:numberOfSubfamilies 20
gptkbp:proteinFamily RTK gene family
gptkbp:subclassOf protein kinases
receptor proteins
gptkbp:target cancer therapies
targeted therapies
gptkbp:bfsParent gptkb:RTKs
gptkbp:bfsLayer 6