Ras superfamily guanine nucleotide exchange factors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	Ras GEFs guanine nucleotide exchange factors for Ras superfamily
gptkbp:discoveredBy	1990s
gptkbp:domain	gptkb:Dbl_homology_domain CDC25 homology domain Pleckstrin homology domain
gptkbp:example	gptkb:RAPGEF1 gptkb:RAPGEF2 gptkb:RAPGEF3 gptkb:RAPGEF4 gptkb:RAPGEF5 gptkb:RAPGEF6 gptkb:RAPGEF7 gptkb:RAPGEF8 gptkb:RasGRF1 gptkb:RasGRF2 gptkb:RasGRP1 gptkb:RasGRP2 gptkb:RasGRP3 gptkb:RasGRP4 gptkb:SOS1
gptkbp:foundIn	eukaryotes
gptkbp:function	activate Ras superfamily GTPases
https://www.w3.org/2000/01/rdf-schema#label	Ras superfamily guanine nucleotide exchange factors
gptkbp:involves	immune response developmental processes oncogenesis neuronal signaling
gptkbp:mechanismOfAction	promote exchange of GDP for GTP
gptkbp:mutationAssociatedWith	gptkb:cancer developmental disorders
gptkbp:regulates	cell differentiation cell proliferation cell migration phosphorylation protein-protein interactions cell signaling pathways cytoskeletal organization lipid binding
gptkbp:relatedTo	signal transduction GTPase cycle
gptkbp:target	gptkb:Ras_GTPases gptkb:Rab_GTPases gptkb:Rho_GTPases gptkb:Arf_GTPases gptkb:Ran_GTPases
gptkbp:bfsParent	gptkb:Ras_superfamily_GEFs
gptkbp:bfsLayer	7