|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:Rap1
gptkb:Ras
|
|
gptkbp:alternativeName
|
gptkb:CalDAG-GEFI
Calcium and diacylglycerol-regulated guanine nucleotide exchange factor I
Ras guanyl-releasing protein 2
|
|
gptkbp:associatedWith
|
bleeding disorders
platelet dysfunction
|
|
gptkbp:domain
|
gptkb:C1_domain
gptkb:EF-hand_domain
CDC25 domain
REM domain
|
|
gptkbp:Entrez_Gene_ID
|
10236
ENSG00000136158
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
brain
platelets
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:gene
|
RAS guanyl releasing protein 2
RASGRP2
|
|
gptkbp:HGNC_ID
|
9882
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RasGRP2
|
|
gptkbp:interactsWith
|
gptkb:Rap1
gptkb:Ras
calcium
diacylglycerol
|
|
gptkbp:involves
|
gptkb:T_cell_receptor_signaling_pathway
signal transduction
platelet activation
|
|
gptkbp:length
|
609
|
|
gptkbp:locatedOnChromosome
|
11q13.1
|
|
gptkbp:molecularWeight
|
68 kDa
|
|
gptkbp:mutationAssociatedWith
|
platelet-type bleeding disorder 18
|
|
gptkbp:OMIM
|
603962
|
|
gptkbp:orthologInMouse
|
Rasgrp2
|
|
gptkbp:PDB
|
6N1C
|
|
gptkbp:phosphorylates
|
Ser394
Ser554
Ser587
|
|
gptkbp:regulates
|
phosphorylation
activated by diacylglycerol
activated by calcium
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
O14827
|
|
gptkbp:bfsParent
|
gptkb:GEFs
gptkb:RasGRP
|
|
gptkbp:bfsLayer
|
7
|