Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:domain |
gptkb:Sec7_domain
CDC25 homology domain DH (Dbl homology) domain |
| gptkbp:example |
gptkb:Epac
gptkb:RasGRP gptkb:Tiam1 gptkb:GEF-H1 gptkb:RCC1 gptkb:RasGRF1 gptkb:Vav gptkb:SOS1 gptkb:ARNO |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:fullName |
gptkb:Ras_superfamily_guanine_nucleotide_exchange_factors
|
| gptkbp:function |
activate Ras superfamily GTPases
|
| https://www.w3.org/2000/01/rdf-schema#label |
Ras superfamily GEFs
|
| gptkbp:mechanismOfAction |
facilitate exchange of GDP for GTP
|
| gptkbp:regulates |
cell differentiation
cell proliferation cell migration cell signaling cytoskeletal organization |
| gptkbp:relatedTo |
gptkb:cancer
signal transduction oncogenesis |
| gptkbp:target |
gptkb:Ras_GTPases
gptkb:Rab_GTPases gptkb:Rho_GTPases gptkb:Arf_GTPases gptkb:Ran_GTPases |
| gptkbp:bfsParent |
gptkb:Ral_guanine_nucleotide_exchange_factors
|
| gptkbp:bfsLayer |
6
|