|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alsoKnownAs
|
gptkb:Ras_proteins
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Weinberg
gptkb:Michael_Wigler
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
gptkb:NRAS_gene
gptkb:KRAS_gene
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
signal transduction
GTPase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras family proteins
|
|
gptkbp:involvedIn
|
gptkb:Ral-GDS_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
cellular signaling
|
|
gptkbp:locale
|
gptkb:plasma_membrane
endomembranes
|
|
gptkbp:member
|
gptkb:MRAS
gptkb:RALA
gptkb:RALB
gptkb:RAP1A
gptkb:RAP1B
gptkb:RAP2A
gptkb:RAP2B
gptkb:RAP2C
gptkb:RIT1
gptkb:RIT2
gptkb:RRAS
gptkb:RRAS2
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
RERG
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Costello_syndrome
gptkb:Noonan_syndrome
gptkb:RASopathies
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
prenylation
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
cell survival
cell migration
cytoskeletal organization
|
|
gptkbp:requires
|
embryonic development
tissue homeostasis
|
|
gptkbp:structure
|
G domain
switch I region
switch II region
|
|
gptkbp:subfamily
|
gptkb:Ras_subfamily
|
|
gptkbp:superfamily
|
gptkb:small_GTPase_superfamily
|
|
gptkbp:target
|
farnesyltransferase inhibitors
anticancer drugs
|
|
gptkbp:bfsParent
|
gptkb:RGL2
|
|
gptkbp:bfsLayer
|
7
|