|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:RAF_proto-oncogene_serine/threonine-protein_kinase
gptkb:c-RAF
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
melanoma
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
ATP binding
apoptosis regulation
protein kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:encodedBy
|
gptkb:RAF1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000132155
5894
|
|
gptkbp:function
|
signal transduction
serine/threonine-protein kinase
|
|
gptkbp:gene
|
gptkb:RAF1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
9829
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAF1 (human)
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:AKT1
gptkb:RAS_proteins
gptkb:BCL2
|
|
gptkbp:involves
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:length
|
648
|
|
gptkbp:locatedOnChromosome
|
3p25
|
|
gptkbp:molecularWeight
|
73 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:LEOPARD_syndrome
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Raf1
|
|
gptkbp:PDB
|
gptkb:3OMV
gptkb:4G0N
|
|
gptkbp:phosphorylates
|
MAP2K1 (MEK1)
MAP2K2 (MEK2)
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
regulated by phosphorylation
activated by RAS
inhibited by 14-3-3 proteins
|
|
gptkbp:UniProtID
|
gptkb:P04049
|
|
gptkbp:bfsParent
|
gptkb:Caenorhabditis_elegans_(lin-45)
|
|
gptkbp:bfsLayer
|
6
|